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    • 专利摘要:
    The invention relates to the use of starch propanoate as an additive and / or dietary supplement for humans for the prevention of overweight and obesity or as a slimming agent. Starch propanoate acts as a platform for the release of propanoic acid in the colon, passing through the upper digestive tract before cleaving propanoic acid in the colon. Propanoic acid released in the colon stimulates the intestinal wall to release appetite suppressant hormones GLP-1 (GLP-2) and PYY, while absorbing propanoic acid into the bloodstream. Increased amount of propanoic acid in the blood inhibits the fat production of the liver and adipose tissue. The increased concentration of propanoic acid in the colon stimulates the intestine to produce appetite-suppressing hormones with reduced calorie intake as a result, and inhibits the production of fat by the liver and adipose tissue. Starch propanoate can thus be used to reduce appetite and calorie intake in humans and thus be used to prevent overweight and obesity.
    公开号:DK202000215A1
    申请号:DKP202000215
    申请日:2020-02-21
    公开日:2021-10-14
    发明作者:Sander Wilbek Theis；Abildgaard Ole
    申请人:Sander Wilbek Theis；Abildgaard Ole；
    IPC主号:
    专利说明:

    [9] [9]. This corresponds to an increased amount of propanoic acid of 0.8 g. This amount of dietary fiber / resistant starch (28-34 g dry weight) is at the limit of what it is possible to consume carbohydrates (in the form of resistant starch or soluble fibers) for fermentation in the colon, without causing severe discomfort [9].
    Starch propanoate ingested in 30 g (20% water content, 8% propanoic acid) thus increases total propanoic acid in the colon by 2 - 2.6 g, where 30 g resistant starch (dry weight) only increases by 0 - 0.8 g propanoic acid. Ie. that starch propanoate is over 3 times as effective in increasing the amount of propanoic acid in the colon in relation to eating the maximum amount of resistant starch (or dietary fiber) that is possible without getting stomach complications. This is further provided that there are the right bacteria to prevent
    DK 2020 00215 A1 take the fermentation of the resistant starch in the colon, which is rare in people who are overweight and are on a western diet. If these bacteria are not present, the difference in effect will thus be much greater, as starch propanoate will still yield 2 g which is cleaved directly, but not a further 0.6 g - while the resistant starch which is now not fermented delivers 0 g. 5 This unfavorable composition of bacteria is probably the reason why the majority of overweight people who eat a modern western diet do not lose weight with increased intake of resistant starch or soluble fiber.
    Thus, the effect of starch propanoate cannot be equated with resistant starch and the use and the effect described in claims 1-10 thus differ from the use and effect of resistant starch. Thus, we use starch propanoate to deliver propanoic acid to the colon to achieve the effects described in claims 1-10. The ester bonds of the propanoic acid are cleaved in the colon and the propanoic acid is released. It is this that substantially increases the amount of propanoic acid and makes it possible to use starch propanoate for claims 1-10. Thus, the main purpose of the esterification of the starch with propanoic acid is not to convert the starch into resistant starch and to obtain fermentation of this, but to obtain the release of propanoic acid directly into the colon in larger quantities and independently of the composition of the bacterial flora.
    20In addition to the fact that starch propanoate is a much more effective method of increasing the amount of propanoic acid in the colon in relation to resistant starch and dietary fiber, starch propanoate also ensures an increase in propanoic acid regardless of the person's intestinal flora / bacterial composition. The intestinal flora / bacterial composition will typically be problematic in relation to efficient fermentation of resistant starch if a person is on a western diet and is overweight.
    Inulin propanoate and cellulose propanoate are the closest known techniques to starch propanoate and they are far from the same products, despite the fact that they are all carbohydrates esterified with propanoic acid. They differ in several respects, including chemical, their solubility, use, manufacturing technique, price, availability for low-income groups, as well as food safety and the possibility of 30 approval as a new food. Thus, starch propanoate differs significantly from the closest known techniques, Chemical: Inoline consists of linked fructose units, cellulose is a linear polymer of glucose units put together via 13-1-4 bonds and starch is a mixture of amylose and amylose.
    DK 2020 00215 A1 6 opectin. Thus, the chemical content of starch propanoate differs from both inulin propanoate and cell dose propanoate. Solubility: Inulin is soluble in water, whereas cellulose and starch are insoluble. However, this also applies to inulin propanoate, cellulose propanoate and starch propanoate, which gives these products different uses. Use: Inulin propane can, for example, be added to soluble soft drinks without changing the transparency or appearance of the soft drink, where this is not the case for cellulose propanoate and starch propanoate, which are partly insoluble and will form precipitates and will partly change the appearance of end the product. As a food additive, inulin propane thus has other uses than starch propane. Cellulose is not fermented in the large intestine and will thus not give increased formation of gases and possibly accompanying discomfort with inulin propanoate and pathway propanoate.
    Production technology: That inulin propanoate is soluble in water and starch propanate is insoluble At the same time, it indicates that starch propanate can be produced much more simply and efficiently than inulin propanoate. Starch propanoate can be produced on already available production equipment used in the food industry for the production of acetylated starch (e-number F1420). existing facilities. This is not the case for imdine propanoate, where specially designed equipment is required. For cellulose propanate, no techniques have been developed for its preparation for food use. It is conceivable that it can be produced in a comparable manner with starch propanoate, if the comic quality is used, but according to the current type of cellulose propanoate used in the plastics industry, this is produced using organic solvents, which requires other equipment, purification and increases the price and complicates the manufacture in terms of starch propanoate. Price: The price for starch propanoate will also be comparable to acetylated starch and is estimated to be 5-10 dkk / kg. When consuming 30 grams per day of starch propanoate, the annual expense for the consumer will be in the order of DKK 200-500, when marketing, retail sales and profits are included. The largest material cost for starch propanoate is starch, which is extracted very cheaply from potatoes. This is not the case for inulin propanoate, where costly special facilities are required. The process described in patent D6 is as follows: Propanoic anhydride reacts with inulin dissolved in water. To get it separated from the residual products, including
    DK 2020 00215 A1 7 acid, it is passed through an activated carbon column where it is collected. It is then rinsed / washed out and spray dried or freeze dried from soluble form in water to obtain a powder form. The basic price for the raw materials on sale alone is between 300-500 dkk / kg for inulin. Inulin is extracted from chicory root which is washed, comminuted, acid-treated and washed - so that the inulin is washed out, carbonized, purified, evaporated and freeze-dried or spray-dried. As the production of inulin propancate also has several process steps that take place at purpose-built process plants, it is estimated that the finished product will have a production price of 500-800 dkk / kg. The sale price will thus hardly fall below DKK 1,000 / kg. Consuming 10 grams per day will mean an annual cost for the consumer in the order of at least 6,000-10,000 dkk, when marketing, retail and 10 profits are included, Cellulose is also a more expensive raw material a starch with several complicated purification steps and is available in many different qualities . Food quality in raw material sales costs microcrystalline cellulose approx. 20-35 dkk / kg, which is more than ten times the price for raw material sales of starch. If this factor is used to calculate a potential annual cost of cellulose propanoate in relation to starch propanoate, an annual cost of cellulose propanoate will be 2,000-5,000 dkk.
    Accessibility for low-income groups: Due to the low price, starch propanoate is in terms of price Unavailable to individuals with limited financial resources - including especially low-income groups in the western economies and developing countries. , Southeast Asia, Central Asia, China, Latin America - 20ka, Middle East, etc.) where the obesity epidemic is particularly prevalent. In 2016, the WHO estimated that the overweight and obese proportion of the earth's population over the age of 18 amounted to approx. 1.9 billion people. Starch propancate will thus potentially be available in terms of price to over 2 billion people in the world who suffer from obesity and overweight. The price of inulin propane and cellulose propanoate means that it will only be available to high-income groups in the aforementioned countries, as well as normal income groups in the western world. market in the West, but will not be widely available to all income groups worldwide - as starch propancet is.
    30Food safety and approval: Regarding For food safety and approval as a new food / food additive, starch propanoate has the very clear advantage that modified starches have been available and used since the 1960s. Thus, the food safety of comparable products is known and an approval of starch propanocat will be able to lean on this knowledge and build on this, and, as mentioned above, apply the same production process - which in turn is an advantage when applying for food approval. This is not the case for inudlinpropanoate,
    DK 2020 00215 A1 8 which will require a more comprehensive arhejde to be approved. The same, varying according to the manufacturing technique, applies to cellulose propanoate. Approval of inulin propanoate as a new food has been submitted, but delayed due to the need for further studies, as well as a better account of the manufacturing process, which as far as is known has not yet been finally determined (presumably because the final process plant has not been designed and tested ). Finally, starch propanoate solves a problem of general health economic interest. Health economists today are largely concerned with the question of “how to treat millions of obese people around the world with low annual incomes so as to mitigate the worldwide 10th obesity epidemic, including some of the resulting catastrophic effects on public health. it and the national health budgets ”. Inulin propanoate and cellulose propanoate cannot solve this question / problem from the price aspect, it can in turn starch propanoate. Starch butanoate has also not been used in research focusing on weight loss and preventing obesity, obesity and weight gain. If starch propanocate is compared in relation to starch butanoate, however, for this purpose, starch propanoate has, among other things, the advantage that the amount of propanoic acid released will promote gluconeogenesis, which butanoic acid does not. Starch propanoate also has better organoleptic properties, as even small amounts of butanoic acid, either not removed by purification or released with minimal degradation, will make starch butanoate smell awful. This is not the case for starch propanoate, in that propanoic acid does not have the same malodorous properties as butanoic acid. Propanoic acid is also cheaper and more readily available than butanoic acid, which reduces production costs and thus the selling price of starch propanoate in relation to butylated starch. Propanoic acid is produced and sold in large quantities, as it is used, among other things, to preserve grain in agriculture.
    Extended publications
    1. Filippo C, Cavalieri D, Di Paola M, et al. Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa. Proc Natl Acad Sci U S A. 2010; 107 (33): 14691—14696. doi: 10.1073 / pnas.1005963107
    2. Hjorth MF, Roager HM, LarsenTM, et al. Pre-treatment microbial Prevotella-to-Bacteroides ratio, determines body fat loss success during a 6-month randomized controlled diet intervention [ublished correction appears in Int J Obes (Lond). 2018 Feb 06 ;:]. Int J Obes (London). 2018; 42 (3): 580—583. doi: 10.1038 / ijo.2017.220
    3. Patent 2013-07-31PCT / GB2013 / 052056
    4. Chambers ES, Viardot A, Psichas A, et al. Effects of targeted delivery of propionate to the human colon on appetite regulation, body weight maintenance and adiposity in overweight adults. Gut. 52015; 64 (11): 1744—1754. doi: 10.1136 / gutjnl-2014-307913.
    5. Byrne CS, Chambers ES, Alhabeeb H, et al. Increased colonic propionate reduces anticipatory reward responses in the human striatum to high-energy foods. Am J Clin Nutr. 2016; 104 (1): € 53 ° 14. doi: 10.3945 / ajen. 115.126706
    106. Byrne CS, Chambers ES, Preston T, et al. Effects of Inulin Propionate Ester Incorporated into Palatable Food Products on Appetite and Resting Energy Expenditure: A Randomized Crossover Study. Nutrients. 2019; 11 (4): 861. Published 2019 Apr 16. doi: 10.3390 / nu11040861
    7. Cummings, John H .; Macfarlane, George T.da; Englyst, Hans N. (2001). "Prebiotic digestion and 15fermentation". Am J Clin Nutr. 73 (suppl): 4158—420S. doi: 10.1093 / ajcn / 73.2.415s. PMID
    11157351.
    8. Morrison DJ, Preston T. Formation of short chain fatty acids by the gut microbiota and their impact on human metabolism. Good Microbes. 2016; 7 (3): 189-200. 20d0i: 10. 1080/19490976. 2015. 1134082
    3. Baxter NT, Schmidt AW, Venkataraman A, Kim KS, Waldron C, SchmidtTM. 2019. Dynamics of human gut microbiota and short-chain fatty acids in response to dietary interventions with three fermentable fibers. mBio 10: 002566-18, htips: //doi.org/10. 1128 / mBio.02566-18.
    权利要求:
    Claims (3)
    [1]
    Starch propanoate used as an additive and / or dietary supplement for humans for the prevention of overweight and obesity.
    [2]
    The use as an additive and / or dietary supplement according to claim 1, characterized by used - as a slimming agent.
    [3]
    The use as an additive and / or dietary supplement according to claim 1, characterized by being used to increase the feeling of satiety and lower the appetite.
    The use as an additive and / or dietary supplement according to claim 1, characterized by being used to reduce food and calorie intake.
    The use as an additive and / or dietary supplement according to claim 1, characterized by being used to reduce the intra-abdominal fat distribution and reduce the amount of intrahepatocellular fat.
    The use as an additive and / or dietary supplement according to claim 1, characterized by being used to increase insulin sensitivity and / or prevent a decrease in insulin sensitivity.
    The use as an additive and / or dietary supplement according to claim 1, characterized by being used to reduce the craving for high-energy foods.
    The use as an additive and / or dietary supplement according to claim 1, for the treatment of overweight and obesity.
    The use as an additive and / or dietary supplement according to claim 1, characterized by use - for ingestion as a suspension or in pill form.
    The use as an additive and / or dietary supplement according to claim 1, characterized by the intake of up to 50g daily by ingestion at once or in several smaller doses.
    NEWS SURVEY REPORT - PATENT Application number PA 2020 00215 i. [] Non-searchable requirements (see box no. 1).
    U] Inventive unit is missing before the news survey (see box no. ID). A. CLASSIFICATION A61K 31/19 (2006.01), A23L 33/12 (2016.01), A61K 47/26 (2006.01), A61P 3/04 (2006.01) According to International Patent Classification (IPC) B. => EXAMINATION AREA PCT minimum documentation examined (classification system followed by classification symbols) IPC & CPC: A61K, A61P, A23L Examined documentation in addition to PCT minimum DK, NO, SE, FI: IPC classes as stated above, Electronic databases used (name of database and possible search terms) EPODOC, WPI , FULL TEXT ENGLISH-LANGUAGE PATENTS, PUBMED C. RELEVANT DOCUMENTS Cited documents evt. with indication of relevant sections Relevant to requirement no. A WO 2014/020344 A1 (IMPERIAL INNOVATIONS LIMITED et al.) 06 February 1-10
    2014. See requirements 1, 2, 7, 10, I1, 18 A DK 2020/00170 Al (THEIS SANDER WILBEK et al.) 21 February 2020. See requirements 1-10 1,3,5,9, 10 A WO 8313801 A1 (COMMONWEALTH SCIENTIFIC AND INDUSTRIAL 1-10 RESEARCH ORGANIZATION) 26 May 1995. See requirements 24, 25, 34, 41 and 44 A EP 1788000 A1 (KAO CORPORATION) 23 May 2007. See requirements 1-10 [] Additional documents is listed in the continuation of Box C. + Category of cited documents: "per Document published in the period between priority and" A "Document representing the prior art (state of the art) filing date. without prejudice to novelty or significant separation "TT" Document which does not conflict with the application but which is npn Document cited in the application. Cited to understand the basic principle or theory behind "E" Document having filing or priority date prior to the invention. The filing date of the application, which is X Particularly relevant document, the invention has no novelty or ad- published later than the filing date. does not differ significantly from prior art when the document is rated "L" Document which may cast doubt on an alleged priority claim, or won alone. . . which is quoted to determine the date of publication of another Y Particularly relevant document; the invention does not differ significantly document, or cited for other reasons (as specified). from prior art when the document is combined with one or more. 1. documents of the same kind, and the combination of these is close- "o" Document dealing with non-written publication, eg available to the person skilled in the art, exhibitions or films. Å]… "&" Document in the same patent family. The Danish Patent and Trademark Office Date of completion of the news survey Helgeshøj Allé 81 9 June 2020 2630 Taastrup The news survey was conducted by Telephone no. +45 4350 8000 Bodil Hasling Fax no. +45 4350 8001 Telephone no. 43 50 83 75 January 2019 1
    Application number NEWS SURVEY REPORT - PATENT PA 2020 00215 C (Continued). RELEVANT DOCUMENTS Cited documents with indication of relevant sections Relevant for requirement no.
    January 2019 2
    NEWS SURVEY REPORT - PATENT Application number PA 2020 00215 Box no. I Non-searchable requirements The news survey has not been conducted for the following requirements:
    [] Requirement No: because they relate to the derogations and therefore do not require a novelty, specifically:
    Requirements or. because they relate to parts of the patent application that do not live up to BEK $ 13 to such an extent that a meaningful news study cannot be conducted, specifically:
    3.0 Requirements or. for other reasons: Box no. II Inventive unit missing before the news survey Several inventions have been found in the application: January 2019 3
    Application number NEWS SURVEY REPORT - PATENT PA 2020 00215
    SUPPLEMENTARY BOX Continuation of box no. [.] January 2019 4
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    同族专利:
    公开号 | 公开日
    WO2021164832A1|2021-08-26|
    DK180598B1|2021-10-14|
    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    CN1081032C|1996-12-19|2002-03-20|张卫民|Medicinal preparation containing saccharin zinc|
    IN2014DN07752A|2012-02-29|2015-05-15|Ethicon Endo Surgery Inc|
    US11179325B2|2016-12-12|2021-11-23|Gi Dynamics, Inc.|Therapeutic methods involving gastrointestinal implants for administering metabolic agents|
    法律状态:
    2021-10-14| PAT| Application published|Effective date: 20210822 |
    2021-10-14| PME| Patent granted|Effective date: 20211014 |
    优先权:
    申请号 | 申请日 | 专利标题
    DKPA202000215A|DK180598B1|2020-02-21|2020-02-21|Starch propanoate used as an additive and / or dietary supplement for humans for the prevention of overweight and obesity|DKPA202000215A| DK180598B1|2020-02-21|2020-02-21|Starch propanoate used as an additive and / or dietary supplement for humans for the prevention of overweight and obesity|
    PCT/DK2021/050041| WO2021164832A1|2020-02-21|2021-02-13|Starch propionate used as a food additive and/or dietary supplement for prevention of overweight and obesity|
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